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    HEPATITIS VIRUSES

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    HEPATITIS VIRUSES Empty HEPATITIS VIRUSES

    مُساهمة من طرف admin الأربعاء ديسمبر 15, 2010 7:02 pm

    Viral hepatitis
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    Viral hepatitis
    Classification and external resources

    Micrograph showing ground glass hepatocytes, which are seen in chronic hepatitis B infections (a type of viral hepatitis), and represent accumulations of viral antigen in the endoplasmic reticulum. H&E stain.
    ICD-10 B15.-B19.
    ICD-9 070
    MeSH D006525

    Viral hepatitis is liver inflammation due to a viral infection. It may present in acute (recent infection, relatively rapid onset) or chronic forms. The most common causes of viral hepatitis are the five unrelated hepatotropic viruses Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis D, and Hepatitis E. In addition to the hepatitis viruses, other viruses that can also cause hepatitis include Herpes simplex, Cytomegalovirus, Epstein-Barr virus, or Yellow fever.

    A virus previously called Hepatitis G virus is now classified as GB virus C because it does not appear to cause hepatitis.
    Contents
    [hide]

    * 1 Hepatitis viruses
    o 1.1 Hepatitis A
    o 1.2 Hepatitis B
    o 1.3 Hepatitis C
    o 1.4 Hepatitis D
    o 1.5 Hepatitis E
    o 1.6 Hepatitis F virus
    o 1.7 GB virus C
    * 2 Other viruses
    * 3 See also
    * 4 References

    [edit] Hepatitis viruses

    Hepatitis caused by viral means is the most common cause of the disease. Although they are classified under the disease hepatitis, these viruses are not all related.
    Hepatitis viruses HAV HEV HBV HCV HDV
    Transmission Enteric Enteric Parenteral Parenteral Parenteral
    Classification Picornavirus Hepevirus Hepadnavirus Hepacivirus Deltavirus
    Genome +ssRNA +ssRNA +dsDNA +ssRNA -ssRNA
    Antigens HBsAg,HBeAg Core antigen Delta antigen
    Incubation period 15–45 days 15–60 days 45–160 days 15–150 days 30–60 days
    Chronicity No No Yes (uncommon) Yes (common) Yes - with hepatitis B
    [edit] Hepatitis A
    Main article: Hepatitis A

    Hepatitis A or infectious jaundice is caused by hepatitis A virus (HAV), a picornavirus transmitted by the fecal-oral route often associated with ingestion of contaminated food. It causes an acute form of hepatitis and does not have a chronic stage. The patient's immune system makes antibodies against HAV that confer immunity against future infection. People with hepatitis A are advised to rest, stay hydrated and avoid alcohol. A vaccine is available that will prevent HAV infection for up to 10 years. Hepatitis A can be spread through personal contact, consumption of raw sea food or drinking contaminated water. This occurs primarily in third world countries. Strict personal hygiene and the avoidance of raw and unpeeled foods can help prevent an infection. Infected people excrete HAV with their feces two weeks before and one week after the appearance of jaundice. The time between the infection and the start of the illness averages 28 days (ranging from 15 to 50 days),[1] and most recover fully within 2 months, although approximately 15% of sufferers may experience continuous or relapsing symptoms from six months to a year following initial diagnosis.[2]
    [edit] Hepatitis B
    Main article: Hepatitis B

    Hepatitis B is caused by hepatitis B virus, a hepadnavirus that can cause both acute and chronic hepatitis. Chronic hepatitis develops in the 15% of adults who are unable to eliminate the virus after an initial infection. Identified methods of transmission include blood (blood transfusion, now rare), tattoos (both amateur and professionally done), sexually (through sexual intercourse or through contact with blood or bodily fluids), or via mother to child by breast feeding (minimal evidence of transplacental crossing). However, in about half of cases the source of infection cannot be determined. Blood contact can occur by sharing syringes in intravenous drug use, shaving accessories such as razor blades, or touching wounds on infected persons. Needle-exchange programmes have been created in many countries as a form of prevention.

    Patients with chronic hepatitis B have antibodies against hepatitis B, but these antibodies are not enough to clear the infection of the affected liver cells. The continued production of virus combined with antibodies is a likely cause of the immune complex disease seen in these patients. A vaccine is available that will prevent infection from hepatitis B for life. Hepatitis B infections result in 500,000 to 1,200,000 deaths per year worldwide due to the complications of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Hepatitis B is endemic in a number of (mainly South-East Asian) countries, making cirrhosis and hepatocellular carcinoma big killers. There are six treatment options approved by the U.S. Food and Drug Administration (FDA) available for persons with a chronic hepatitis B infection: alpha-interferon, pegylated interferon adefovir, entecavir, telbivudine and lamivudine. About 65% of persons on treatment achieve a sustained response.
    [edit] Hepatitis C
    Main article: Hepatitis C

    Hepatitis C (originally "non-A non-B hepatitis") is caused by hepatitis C virus (HCV), an RNA virus that is a member of the Flaviviridae family. HCV can be transmitted through contact with blood (including through sexual contact if the two parties' blood is mixed) and can also cross the placenta. Hepatitis C usually leads to chronic hepatitis, culminating in cirrhosis in some people. It usually remains asymptomatic for decades. Patients with hepatitis C are susceptible to severe hepatitis if they contract either hepatitis A or B, so all persons with hepatitis C should be immunized against hepatitis A and hepatitis B if they are not already immune, and avoid alcohol. HCV viral levels can be reduced to undetectable levels by a combination of interferon and the antiviral drug ribavirin. The genotype of the virus is the primary determinant of the rate of response to this treatment regimen, with genotype 1 being the most resistant.

    Hepatitis C is the most common chronic blood-borne infection in the United States.[3]
    [edit] Hepatitis D
    Main article: Hepatitis D

    The Hepatitis D virus (HDV) or hepatitis delta agent is similar to a viroid as it can only propagate in the presence of the hepatitis B virus.
    [edit] Hepatitis E
    Main article: Hepatitis E

    The Hepatitis E virus (HEV) produces symptoms similar to hepatitis A, although it can take a fulminant course in some patients, particularly pregnant women; it is more prevalent in the Indian subcontinent.
    [edit] Hepatitis F virus
    Main article: Hepatitis F

    Hepatitis F virus (HFV) is a hypothetical virus linked to hepatitis. Several hepatitis F virus candidates emerged in the 1990s; none of these reports have been substantiated.
    [edit] GB virus C
    Main article: GB virus C

    The GB virus C is another potential viral cause of hepatitis that is probably spread by blood and sexual contact.[4] It was initially identified as Hepatitis G virus.[5] There is very little evidence that this virus causes hepatitis, as it does not appear to replicate primarily in the liver.[6] It is now classified as GB virus C.[7]
    [edit] Other viruses
    Please help improve this article by expanding it. Further information might be found on the talk page. (February 2009)

    Other viruses such as cytomegalovirus, Epstein-Barr virus, and yellow fever may also cause hepatitis, however not to the same extent as the viruses above.[citation needed]
    [edit] See also

    * AST/ALT ratio
    * Ground glass hepatocyte
    * Risk factors in pregnancy

    [edit] References

    1. ^ "CDC Hepatitis A FAQ". [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط] Retrieved 2008-03-03.
    2. ^ "CDC Hepatitis A Fact Sheet". [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط] Retrieved 2008-03-03.
    3. ^ "CDC DVH - Hepatitis C Information For the Health Professional". [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط] Retrieved 2010-01-14.
    4. ^ Stark J, et al. (1996). "Detection of the hepatitis G virus genome among injecting drug users, homosexual and bisexual men, and blood donors". J. Infect. Dis. 174 (6): 1320–3. PMID 8940225.
    5. ^ Linnen J, Wages J, Zhang-Keck ZY, et al. (1996). "Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent". Science (journal) 271 (5248): 505–8. doi:10.1126/science.271.5248.505. PMID 8560265. [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]
    6. ^ Pessoa MG, Terrault NA, Detmer J, et al. (1998). "Quantitation of hepatitis G and C viruses in the liver: evidence that hepatitis G virus is not hepatotropic". Hepatology 27 (3): 877–80. doi:10.1002/hep.510270335. PMID 9500722.
    7. ^ "00.026. Flaviviridae - ICTVdB Index of Viruses". [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]

    [show]
    v • d • e
    Infectious diseases · Viral systemic diseases (A80–B34, 042–079)
    Oncovirus

    DNA virus: HBV (Hepatocellular carcinoma) · HPV (Cervical cancer, Anal cancer) · Kaposi's sarcoma-associated herpesvirus (Kaposi's sarcoma) · Epstein-Barr virus (Nasopharyngeal carcinoma, Burkitt's lymphoma, Primary central nervous system lymphoma) · MCPyV (Merkel cell cancer) · SV40
    RNA virus: HCV (Hepatocellular carcinoma) · HTLV-I (Adult T-cell leukemia/lymphoma)
    Immune disorders
    HIV (AIDS)
    Central
    nervous system
    Encephalitis/
    meningitis

    DNA virus: JCV (Progressive multifocal leukoencephalopathy)
    RNA virus: MeV (Subacute sclerosing panencephalitis) · LCV (Lymphocytic choriomeningitis) · Arbovirus encephalitis · Orthomyxoviridae (probable) (Encephalitis lethargica) · RV (Rabies) · Chandipura virus · Herpesviral meningitis · Ramsay Hunt syndrome type II
    Myelitis

    Poliovirus (Poliomyelitis, Post-polio syndrome) · HTLV-I (Tropical spastic paraparesis)
    Eye

    Cytomegalovirus (Cytomegalovirus retinitis) · HSV (Herpetic keratitis)
    Cardiovascular
    CBV (Pericarditis, Myocarditis)
    Respiratory
    system/
    acute viral
    nasopharyngitis/
    viral pneumonia
    DNA virus

    Epstein-Barr virus (EBV infection/Infectious mononucleosis) · Cytomegalovirus
    RNA virus


    IV: SARS coronavirus (Severe acute respiratory syndrome)

    V, Orthomyxoviridae: Influenzavirus A/B/C (Influenza/Avian influenza)
    V, Paramyxovirus: Human parainfluenza viruses (Parainfluenza) · RSV · hMPV
    Digestive system
    Oropharynx/Esophagus

    MuV (Mumps) · Cytomegalovirus (Cytomegalovirus esophagitis)
    Gastroenteritis/
    diarrhea

    DNA virus: Adenovirus (Adenovirus infection)
    RNA virus: Rotavirus · Norovirus · Astrovirus · Coronavirus
    Hepatitis

    DNA virus: HBV (B)
    RNA virus: CBV · HAV (A) · HCV (C) · HDV (D) · HEV (E) · HGV (G)
    Pancreatitis

    CBV
    Urogenital
    BK virus · MuV (Mumps)

    M: VIR


    virs (prot)


    cutn/syst (hppv, hiva, infl, zost, zoon), epon


    drugJ(dnaa, rnaa, rtva, vacc)
    [show]
    v • d • e
    Digestive system · Digestive disease · Gastroenterology (primarily K20–K93, 530–579)
    Upper GI tract
    Esophagus

    Esophagitis (Candidal, Herpetiform) · rupture (Boerhaave syndrome, Mallory-Weiss syndrome) · UES (Zenker's diverticulum) · LES (Barrett's esophagus) · Esophageal motility disorder (Nutcracker esophagus, Achalasia, Diffuse esophageal spasm, Gastroesophageal reflux disease (GERD)) · Laryngopharyngeal reflux (LPR) · Esophageal stricture · Megaesophagus
    Stomach

    Gastritis (Atrophic, Ménétrier's disease, Gastroenteritis) · Peptic (gastric) ulcer (Cushing ulcer, Dieulafoy's lesion) · Dyspepsia · Pyloric stenosis · Achlorhydria · Gastroparesis · Gastroptosis · Portal hypertensive gastropathy · Gastric antral vascular ectasia · Gastric dumping syndrome · Gastric volvulus
    Lower GI tract:
    Intestinal/
    enteropathy
    Small intestine/
    (duodenum/jejunum/ileum)

    Enteritis (Duodenitis, Jejunitis, Ileitis) — Peptic (duodenal) ulcer (Curling's ulcer) — Malabsorption: Coeliac · Tropical sprue · Blind loop syndrome · Whipple's · Short bowel syndrome · Steatorrhea · Milroy disease
    Large intestine
    (appendix/colon)

    Appendicitis · Colitis (Pseudomembranous, Ulcerative, Ischemic, Microscopic, Collagenous, Lymphocytic) · Functional colonic disease (IBS, Intestinal pseudoobstruction/Ogilvie syndrome) — Megacolon/Toxic megacolon · Diverticulitis/Diverticulosis
    Large and/or small

    Enterocolitis (Necrotizing) · IBD (Crohn's disease) — vascular: Abdominal angina · Mesenteric ischemia · Angiodysplasia — Bowel obstruction: Ileus · Intussusception · Volvulus · Fecal impaction — Constipation · Diarrhea (Infectious) · Intestinal adhesions
    Rectum

    Proctitis (Radiation proctitis) · Proctalgia fugax · Rectal prolapse · Anismus
    Anal canal

    Anal fissure/Anal fistula · Anal abscess · Anal dysplasia · Pruritus ani
    GI bleeding/BIS
    Upper (Hematemesis, Melena) · Lower (Hematochezia)
    Accessory
    Liver

    Hepatitis (Viral hepatitis, Autoimmune hepatitis, Alcoholic hepatitis) · Cirrhosis (PBC) · Fatty liver (NASH) · vascular (Hepatic veno-occlusive disease, Portal hypertension, Nutmeg liver) · Alcoholic liver disease · Liver failure (Hepatic encephalopathy, Acute liver failure) · Liver abscess (Pyogenic, Amoebic) · Hepatorenal syndrome · Peliosis hepatis
    Gallbladder

    Cholecystitis · Gallstones/Cholecystolithiasis · Cholesterolosis · Rokitansky-Aschoff sinuses · Postcholecystectomy syndrome · Porcelain gallbladder
    Bile duct/
    other biliary tree


    Cholangitis (PSC, Secondary sclerosing cholangitis, Ascending) · Cholestasis/Mirizzi's syndrome · Biliary fistula · Haemobilia · Gallstones/Cholelithiasis
    common bile duct (Choledocholithiasis, Biliary dyskinesia) · Sphincter of Oddi dysfunction
    Pancreatic

    Pancreatitis (Acute, Chronic, Hereditary, Pancreatic abscess) · Pancreatic pseudocyst · Exocrine pancreatic insufficiency · Pancreatic fistula
    Abdominopelvic
    Hernia


    Diaphragmatic (Congenital) · Hiatus

    Inguinal (Indirect, Direct) · Umbilical · Femoral · Obturator · Spigelian

    lumbar (Petit's, Grynfeltt-Lesshaft)
    undefined location (Incisional · Internal hernia)
    Peritoneal

    Peritonitis (Spontaneous bacterial peritonitis) · Hemoperitoneum · Pneumoperitoneum

    M: DIG


    anat(t, g, p)/phys/devp/cell/enzy


    noco/cong/tumr, sysi/epon


    proc, drug(A2A/2B/3/4/5/6/7/14/16), blte
    Retrieved from "http://en.wikipedia.org/wiki/Viral_hepatitis"
    Categories: Gastroenterology | Hepatitis
    Hidden categories: Articles to be expanded from February 2009 | All articles to be expanded | All articles with unsourced statements | Articles with unsourced statements from February 2009
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