CLINICAL BIOCHEMISTRY/Urea cycle

Urea cycle








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The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions occurring in many animals that produces urea ((NH₂)₂CO) from ammonia (NH₃). This cycle was the first metabolic cycle discovered (Hans Krebs and Kurt Henseleit, 1932), five years before the discovery of the TCA cycle. In mammals, the urea cycle takes place primarily in the liver, and to a lesser extent in the kidney.





Contents


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• 1 Function
  
• 2 Reactions
  
• 3 Regulation
  
  
  
  • 3.1 N-Acetylglutamic acid
    
  • 3.2 Substrate concentrations
    
  
  
• 4 Pathology
  
• 5 Additional images
  
• 6 External links